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The weight of the device is less than 150g. Phase 1 Fall Sensor Software and Algorithms As the phase 1 trials did not require communication of mobility information to other parts of the CAALYX system, the fall sensor software consisted of the necessary fall algorithms, software to log the measured data on a µSD card on the fall sensor and a communication interface to notify the system of potential trip or fall incidents. The fall algorithm used is based on measuring the acceleration of the user in three degrees of freedom.

82] designed and synthesized a complex nanodevice that experimentally allowed targeted intracellular drug delivery while having an imaging capability for tracking uptake of the material. The device was based on a nanoscale polymer to whose surface folic acid, fluorescein and methotrexate were covalently attached to provide targeting, imaging, and intracellular drug delivery capabilities, respectively. Targeting data in human carcinoma cell lines confirmed the modeling predictions of specific and highly selective binding: targeted delivery improved the cytotoxic response of the cells to methotrexate 100-fold over free drug.

Generally speaking, 50 nm is the upper size threshold to penetrate the vascular endothelium and directly target tissue cells, otherwise intravascular targets are essentially reachable. Tumour vasculature instead, thanks to its peculiar physiopathology, allows effective targeting of cancer cells beyond the capillary endothelium also with bigger NPCA. In fact, a consistent difference between normal vessels and those created by tumour angiogenesis Smart Nano-systems for Tumour Cellular Diagnoses and Therapies 35 is the tendency of the latter to be “leaky” for the EPR (enhanced permeability and retention) effect, which depends on type, location and histologic grade of tumor [26-28].

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