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The unique sequence, Advances in Prostaglandin study, edited by way of Sultan M. M. Karim, was once released through MTP Press in 3 volumes in 1975 and 1976. a look at these books illustrates the growth that has been made on account that then. The thromboxanes have been pointed out two times (first book 1975) and prostacyclin no longer as soon as (first e-book 1976); leukotrienes have been merely at the horizon. The New Role of the Academies of Sciences in the Balkan Countries

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Use of phosphodiesterase inhibitors to evaluate their roles in regUlating cyclic nucleotide levels in intact cells. Biochem. J. 266,127-132. 46. , Moncada, S. (1991) Modulation of platelet aggregation by an arginine: nitric oxide pathway. TIPS, 12,87-88. 47. A. (1990) Prostaglandin endoperoxide/thromboxane A2 receptor desensitization. Cross- talk with adenylate cyclase in human platelets. J. BioI. Chern. 265,21670-21675. 48. R. (1988) Endothelium- derived relaxing factor reduces platelet adhesion to bovine endothelial cells.

Pharmacology of nitric oxide formation and action Under physiological conditions, there is little effect of L -Arg administered acutely on the formation of NO by the intact endothelium and by resting platelets [17,18,24]. This may be due to a high plasma and intracellular content of L- Arg which may down- regulate both transport and activation of NO synthase as well as to the presence of arginase, an enzyme which redirects L- Arg towards metabolites of the urea cycle [107-111]. However, transport of L -Arg into cultured endothelial cells which have previously been depleted of this amino acid is up- regulated and, under these circumstances, L- Arg causes the formation of NO [17,112].

Moncada, S. (1987) Nitric oxide accounts for the biological activity of endothelium - derived relaxing factor. Nature 327,524-526. 9. , Moncada, S. (1987) Comparative pharmacology of EDRF and nitric oxide on vascular strips. Eur. J. Pharmacol. 141,445-451. 10. , Moncada, S. (1987) Comparative pharmacology of endothelium - derived relaxing factor, nitric oxide and prostacyclin in platelets. Br. J. Pharmacol. 92,181-187. 11. , Moncada S. (1987) The anti aggregating properties of vascular endothelium: interactions between prostacyc1in and nitric oxide.

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